Sertraline updated on 07-01-2025

Abdominal wall defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S8217
R25623		 Jordan, 2016 Abdominal wall defects 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.34 [0.19;9.55] C
excluded (exposition period) 		1/1,374   275/506,155 276 1,374
ref
S5888
R14777		 Ban (Controls unexposed, disease free), 2014 Abdominal wall malformations 1st trimester retrospective cohort (claims database) unexposed, disease free Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 4.90 [0.67;36.01] 0/757   69/325,294 69 757
ref
Total 1 studies 4.90 [0.67;35.92] 69 757
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Ban (Controls unexposed, disease free), 2014Ban, 2014 1 4.90[0.67; 36.01]697570%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, disease free;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.90[0.67; 35.92]69757 -NABan (Controls unexposed, disease free), 2014 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 4.90[0.67; 35.92]69757 -NABan (Controls unexposed, disease free), 2014 1 Tags Adjustment   - Yes  - Yes 4.90[0.67; 35.92]69757 -NABan (Controls unexposed, disease free), 2014 1 Monotherapy   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 4.90[0.67; 35.92]69757 -NABan (Controls unexposed, disease free), 2014 1 All studiesAll studies 4.90[0.67; 35.92]69757 -NABan (Controls unexposed, disease free), 2014 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 4.90[0.67; 35.92]69757 -NABan (Controls unexposed, disease free), 2014 10.510.01.0