Sertraline - Medication and Pregnancy KB

Sertraline updated on 07-01-2025

Low Apgar score (< 7) (at 1 min)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S18438 R78194	Lee (Controls exposed to TCAs), 2025	1-minute Apgar score <7	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	exposed to other treatment, sick excluded	Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	0.78 [0.46;1.29] ^C excluded (control group)	28/643 34/613	62	643		ref
S18420 R77952	Lee (Controls unexposed, general pop), 2025	1-minute Apgar score <7	during pregnancy (anytime or not specified)	retrospective cohort (claims database)	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.36 [0.92;2.01]	28/643 14,883/463,440	14,911	643		ref
S7699 R22857	Kivistö, 2016	Low (<7) Apgar score at 1 min	during pregnancy (anytime or not specified)	retrospective cohort	unexposed (general population or NOS)	Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...)	1.30 [0.40;4.24]	-/49 1,451/24,402	-	49		ref
					Total	2 studies	1.35 [0.93;1.96]		14,911	692
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, general pop;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18438