Sertraline updated on 07-01-2025

Microcephaly / Small head circumference for gestational age

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10598
R39106		 Kerr, 2018 Isolated microcephaly (ICD-9 - Within 6 months after delivery) 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.50 [0.04;8.87] 1/142   56/11,974 57 142
ref
S7699
R22867		 Kivistö, 2016 Head circumference <10th centile (in newborns) during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.08 [0.33;3.59] -/-   1,709/- - -
ref
Total 2 studies 1.14 [0.38;3.39] 57 142
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kerr, 2018Kerr, 2018 1.50[0.04; 8.87]5714216%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Kivistö, 2016Kivistö, 2016 1.08[0.33; 3.59]--84%ROB confusion: seriousROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.14[0.38; 3.39]571420.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.08[0.33; 3.56]-- -NAKivistö, 2016 1 case control studiescase control studies 1.50[0.10; 22.34]57142 -NAKerr, 2018 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.14[0.38; 3.39]571420%NAKerr, 2018 Kivistö, 2016 2 Tags Adjustment   - No  - No 1.50[0.10; 22.34]57142 -NAKerr, 2018 1   - Yes  - Yes 1.08[0.33; 3.56]-- -NAKivistö, 2016 1 Monotherapy   - no or not specified  - no or not specified 1.50[0.10; 22.34]57142 -NAKerr, 2018 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.08[0.33; 3.56]-- -NAKivistö, 2016 1 All studiesAll studies 1.14[0.38; 3.39]571420%NAKerr, 2018 Kivistö, 2016 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.14[0.38; 3.39]1,7571420%NAKerr, 2018 Kivistö, 2016 20.510.01.0