Sertraline updated on 07-01-2025

Tetralogy of Fallot

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7468
R22143		 Anderson, 2020 Tetralogy of Fallot 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.74 [1.09;2.78] -/-   0/- - -
ref
S7352
R21543		 Wemakor, 2015 Tetralogy of Fallot 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 3.33 [0.43;25.68] 1/15   427/17,496 428 15
ref
Total 2 studies 1.80 [1.14;2.84] 428 15
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.74[1.09; 2.78]--95%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Wemakor, 2015Wemakor, 2015 3.33[0.43; 25.68]428155%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.80[1.14; 2.84]428150.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.80[1.14; 2.84]428150%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.80[1.14; 2.84]428150%NAAnderson, 2020 Wemakor, 2015 2 Tags Adjustment   - Yes  - Yes 1.80[1.14; 2.84]428150%NAAnderson, 2020 Wemakor, 2015 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.80[1.14; 2.84]428150%NAAnderson, 2020 Wemakor, 2015 2 All studiesAll studies 1.80[1.14; 2.84]428150%NAAnderson, 2020 Wemakor, 2015 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.80[1.14; 2.84]428150%NAAnderson, 2020 Wemakor, 2015 20.510.01.0