Sertraline updated on 07-01-2025

Diaphragmatic hernia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7468
R22193		 Anderson, 2020 Diaphragmatic hernia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.18 [0.63;2.20] -/-   0/- - -
ref
S8217
R25651		 Jordan, 2016 Diaphragmatic hernia 3 months or more before pregnancy or1st trimester excluded retrospective cohort (registry) unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 2.88 [0.40;20.61] C
excluded (exposition period) 		1/1,374   128/506,155 129 1,374
ref
S6159
R16165		 Louik, 2007 Diaphragmatic hernia 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.50 [0.20;11.50] 1/47   191/6,005 192 47
ref
Total 2 studies 1.20 [0.66;2.19] 192 47
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.18[0.63; 2.20]--91%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Louik, 2007Louik, 2007 1.50[0.20; 11.50]192479%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.20[0.66; 2.19]192470.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.20[0.66; 2.19]192470%NAAnderson, 2020 Louik, 2007 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.20[0.66; 2.19]192470%NAAnderson, 2020 Louik, 2007 2 Tags Adjustment   - Yes  - Yes 1.20[0.66; 2.19]192470%NAAnderson, 2020 Louik, 2007 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.18[0.63; 2.21]-- -NAAnderson, 2020 1   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 1.50[0.20; 11.37]19247 -NALouik, 2007 1 All studiesAll studies 1.20[0.66; 2.19]192470%NAAnderson, 2020 Louik, 2007 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.20[0.66; 2.19]192470%NAAnderson, 2020 Louik, 2007 20.510.01.0