Sertraline updated on 07-01-2025

Neonatal death (< 28 days of life)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S18438
R78198		 Lee (Controls exposed to TCAs), 2025 Neonatal death (≤28 days after birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.95 [0.02;48.12] C
excluded (control group) 		0/643   0/613 0 643
ref
S18420
R77956		 Lee (Controls unexposed, general pop), 2025 Neonatal death (≤28 days after birth) during pregnancy (anytime or not specified) retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 0.57 [0.04;9.20] C 0/643   627/463,440 627 643
ref
S7927
R23994		 Stephansson, 2013 Neonatal death (death within 0-27 days among live born infants) 3 months (or more) before pregnancy or during pregnancy excluded population based cohort retrospective unexposed (general population or NOS) Adjustment: No Monotherapy: no or not specified 1.38 [0.84;2.25] C
excluded (exposition period) 		16/5,278   3,535/1,604,649 3,551 5,278
ref
Total 1 studies 0.57 [0.04;9.20] 627 643
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lee (Controls unexposed, general pop), 2025Lee, 2025 1 0.57[0.04; 9.20]6276430%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Controls unexposed, general pop;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.57[0.04; 9.20]627643 -NALee (Controls unexposed, general pop), 2025 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.57[0.04; 9.20]627643 -NALee (Controls unexposed, general pop), 2025 1 Tags Adjustment   - No  - No 0.57[0.04; 9.20]627643 -NALee (Controls unexposed, general pop), 2025 1 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 0.57[0.04; 9.20]627643 -NALee (Controls unexposed, general pop), 2025 1 All studiesAll studies 0.57[0.04; 9.20]627643 -NALee (Controls unexposed, general pop), 2025 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 18438

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.57[0.04; 9.20]627643 -NALee (Controls unexposed, general pop), 2025 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.95[0.02; 48.12]-643 -NALee (Controls exposed to TCAs), 2025 10.510.01.0