Sertraline updated on 07-01-2025

Atrioventricular septal defect

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S7468
R22147		 Anderson, 2020 Atrioventricular septal defect 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.17 [0.48;2.90] -/-   0/- - -
ref
S6008
R15427		 Furu, 2015 Atrioventricular septal defects 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.81 [0.80;4.06] 6/7,245   1,073/2,266,875 1,079 7,245
ref
S7352
R21548		 Wemakor, 2015 Atrioventricular septal defect 1st trimester case control unexposed (general population or NOS) Adjustment: No Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 4.22 [0.55;32.19] C 1/15   289/17,358 290 15
ref
Total 3 studies 1.62 [0.91;2.88] 1,369 7,260
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Anderson, 2020Anderson, 2020 1.17[0.48; 2.90]--41%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: unclearROB reporting: moderate Furu, 2015Furu, 2015 1.81[0.80; 4.06]1,0797,24551%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Wemakor, 2015Wemakor, 2015 4.22[0.55; 32.19]290158%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.62[0.91; 2.88]1,3697,2600.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.81[0.80; 4.08]1,0797,245 -NAFuru, 2015 1 case control studiescase control studies 1.59[0.54; 4.62]2901522%NAAnderson, 2020 Wemakor, 2015 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.62[0.91; 2.88]1,3697,2600%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 3 Tags Adjustment   - No  - No 4.22[0.55; 32.19]29015 -NAWemakor, 2015 1   - Yes  - Yes 1.49[0.81; 2.72]1,0797,2450%NAAnderson, 2020 Furu, 2015 2 Monotherapy   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.62[0.91; 2.88]1,3697,2600%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 3 All studiesAll studies 1.62[0.91; 2.88]1,3697,2600%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.62[0.91; 2.88]1,3697,2600%NAAnderson, 2020 Furu, 2015 Wemakor, 2015 30.510.01.0