Sertraline updated on 07-01-2025

Club foot / Talipes equinovarus

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S6008
R15432		 Furu, 2015 Clubfoot 1st trimester population based cohort retrospective unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 1.76 [1.10;2.81] 21/7,245   3,174/2,266,875 3,195 7,245
ref
S7352
R21531		 Wemakor, 2015 Club foot 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among all Antidep (SSRI, SNRI, ...) 3.05 [1.09;8.52] 5/19   1,987/19,056 1,992 19
ref
S7905
R23942		 Yazdy, 2014 Club foot 1st trimester case control unexposed, disease free Adjustment: Yes Monotherapy: no or not specified 1.60 [0.80;3.20] 13/39   609/2,585 622 39
ref
S6159
R16160		 Louik, 2007 Clubfoot 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Monotherapy: substance alone among the specific class of antidep (SSRI, SNRI, ...) 2.40 [0.90;6.20] 5/51   408/6,222 413 51
ref
Total 4 studies 1.90 [1.35;2.67] 6,222 7,354
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Furu, 2015Furu, 2015 1.76[1.10; 2.81]3,1957,24553%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Wemakor, 2015Wemakor, 2015 3.05[1.09; 8.52]1,9921911%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Yazdy, 2014Yazdy, 2014 1.60[0.80; 3.20]6223924%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Louik, 2007Louik, 2007 2.40[0.90; 6.20]4135112%ROB confusion: moderateROB selection: criticalROB classification: criticalROB missing: lowROB mesure: criticalROB reporting: moderate Total (4 studies) I2 = 0% 1.90[1.35; 2.67]6,2227,3540.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.76[1.10; 2.81]3,1957,245 -NAFuru, 2015 1 case control studiescase control studies 2.06[1.26; 3.38]3,0271090%NAWemakor, 2015 Yazdy, 2014 Louik, 2007 3 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.90[1.35; 2.67]6,2227,3540%NAFuru, 2015 Wemakor, 2015 Yazdy, 2014 Louik, 2007 4 Tags Adjustment   - Yes  - Yes 1.90[1.35; 2.67]6,2227,3540%NAFuru, 2015 Wemakor, 2015 Yazdy, 2014 Louik, 2007 4 Monotherapy   - no or not specified  - no or not specified 1.60[0.80; 3.20]62239 -NAYazdy, 2014 1   - substance alone among all Antidep ( ...  - substance alone among all Antidep (SSRI, SNRI, ...) 1.93[1.26; 2.96]5,1877,2640%NAFuru, 2015 Wemakor, 2015 2   - substance alone among the specific ...  - substance alone among the specific class of antidep (SSRI, SNRI, ...) 2.40[0.91; 6.30]41351 -NALouik, 2007 1 All studiesAll studies 1.90[1.35; 2.67]6,2227,3540%NAFuru, 2015 Wemakor, 2015 Yazdy, 2014 Louik, 2007 40.510.01.0

Publication bias and p-hacking diagnosis

funnel plot
0.0-1.31.90.6290.000Furu, 2015Wemakor, 2015Yazdy, 2014Louik, 2007

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot
0.01.00.01.0

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.90[1.35; 2.67]6,2227,3540%NAFuru, 2015 Wemakor, 2015 Yazdy, 2014 Louik, 2007 40.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Chen (Clubfoot)Chen (Clubfoot) 1.90[1.35; 2.67]0 %-Wwhatever (meta-analysis)T11st trimesterstudies TTT4 metaPregmetaPreg 1.90[1.35; 2.67]0%7,354----Furu, 2015 Wemakor, 2015 Yazdy, 2014 Louik, 2007 40.510.01.0