Miconazole (local route only) updated on 01-29-2025

Digestive system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17578
R74148		 Rotem, 2018 Gastrointestinal system 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Route of exposure Azoles: Vaginal 2.05 [0.51;8.29] C 2/313   299/95,781 301 313
ref
Total 1 studies 2.05 [0.51;8.29] 301 313
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rotem, 2018Rotem, 2018 2.05[0.51; 8.29]3013130%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.05[0.51; 8.29]301313 -NARotem, 2018 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.05[0.51; 8.29]301313 -NARotem, 2018 1 Tags Adjustment   - No  - No 2.05[0.51; 8.29]301313 -NARotem, 2018 1 Route of exposure Azoles   - Vaginal  - Vaginal 2.05[0.51; 8.29]301313 -NARotem, 2018 1 All studiesAll studies 2.05[0.51; 8.29]301313 -NARotem, 2018 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.05[0.51; 8.29]301313 -NARotem, 2018 10.510.01.0