Miconazole (local route only) updated on 01-29-2025

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17578
R74144		 Rotem, 2018 Cardiovascular system 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes Route of exposure Azoles: Vaginal 1.12 [0.58;2.18] 9/313   2,398/95,781 2,407 313
ref
S17577
R74134		 Kazy, 2005 Cardiovascular congenital anomalies 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Co-administration Matched Route of exposure Azoles: Vaginal 1.10 [0.60;1.80] 27/230   4,452/42,400 4,479 230
ref
Total 2 studies 1.11 [0.73;1.69] 6,886 543
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rotem, 2018Rotem, 2018 1.12[0.58; 2.18]2,40731341%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Kazy, 2005Kazy, 2005 1.10[0.60; 1.80]4,47923059%ROB confusion: unclearROB selection: criticalROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.11[0.73; 1.69]6,8865430.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.12[0.58; 2.17]2,407313 -NARotem, 2018 1 case control studiescase control studies 1.10[0.64; 1.91]4,479230 -NAKazy, 2005 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.11[0.73; 1.69]6,8865430%NARotem, 2018 Kazy, 2005 2 Tags Adjustment   - Yes  - Yes 1.11[0.73; 1.69]6,8865430%NARotem, 2018 Kazy, 2005 2 Co-administrationCo-administration 1.10[0.64; 1.91]4,479230 -NAKazy, 2005 1 MatchedMatched 1.10[0.64; 1.91]4,479230 -NAKazy, 2005 1 Route of exposure Azoles   - Vaginal  - Vaginal 1.11[0.73; 1.69]6,8865430%NARotem, 2018 Kazy, 2005 2 All studiesAll studies 1.11[0.73; 1.69]6,8865430%NARotem, 2018 Kazy, 2005 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.11[0.73; 1.69]6,8865430%NARotem, 2018 Kazy, 2005 20.510.01.0