Miconazole (local route only) updated on 01-29-2025

Cleft lip with or without cleft palate

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17578
R74150		 Rotem, 2018 Cleft lip/palate 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No Route of exposure Azoles: Vaginal 4.88 [1.20;19.82] C 2/313   126/95,781 128 313
ref
S17577
R74122		 Kazy, 2005 Cleft lip with or without palate 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Co-administration Matched Route of exposure Azoles: Vaginal 1.70 [0.80;3.70] 14/217   1,360/39,308 1,374 217
ref
Total 2 studies 2.43 [0.91;6.47] 1,502 530
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rotem, 2018Rotem, 2018 4.88[1.20; 19.82]12831334%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Kazy, 2005Kazy, 2005 1.70[0.80; 3.70]1,37421766%ROB confusion: unclearROB selection: criticalROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 40% 2.43[0.91; 6.47]1,5025300.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 4.88[1.20; 19.82]128313 -NARotem, 2018 1 case control studiescase control studies 1.70[0.79; 3.66]1,374217 -NAKazy, 2005 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.43[0.91; 6.47]1,50253040%NARotem, 2018 Kazy, 2005 2 Tags Adjustment   - No  - No 4.88[1.20; 19.82]128313 -NARotem, 2018 1   - Yes  - Yes 1.70[0.79; 3.66]1,374217 -NAKazy, 2005 1 Co-administrationCo-administration 1.70[0.79; 3.66]1,374217 -NAKazy, 2005 1 MatchedMatched 1.70[0.79; 3.66]1,374217 -NAKazy, 2005 1 Route of exposure Azoles   - Vaginal  - Vaginal 2.43[0.91; 6.47]1,50253040%NARotem, 2018 Kazy, 2005 2 All studiesAll studies 2.43[0.91; 6.47]1,50253040%NARotem, 2018 Kazy, 2005 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.43[0.91; 6.47]1,50253040%NARotem, 2018 Kazy, 2005 20.510.01.0