Miconazole (all routes except local only) updated on 01-29-2025

All congenital malformations (majors, minors, majors and minors, or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17573
R74100		 Rosa, 1987 Birth defects 1st trimester case control unexposed (general population or NOS) Adjustment: No 1.02 [0.90;1.20] 144/2,236   6,420/102,103 6,564 2,236
ref
Total 1 studies 1.02 [0.88;1.18] 6,564 2,236
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Rosa, 1987Rosa, 1987 1.02[0.90; 1.20]6,5642,2360%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: critical0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.02[0.88; 1.18]6,5642,236 -NARosa, 1987 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.02[0.88; 1.18]6,5642,236 -NARosa, 1987 1 Tags Adjustment   - No  - No 1.02[0.88; 1.18]6,5642,236 -NARosa, 1987 1 All studiesAll studies 1.02[0.88; 1.18]6,5642,236 -NARosa, 1987 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.02[0.88; 1.18]6,5642,236 -NARosa, 1987 10.510.01.0