Butoconazole updated on 01-29-2025

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S10629
R39309		 Carter, 2008 Cardiovascular defects 1st trimester case control unexposed (general population or NOS) Adjustment: No Route of exposure Azoles: Vaginal 0.52 [0.02;12.81] C 0/1   3,049/7,822 3,049 1
ref
Total 1 studies 0.52 [0.02;12.81] 3,049 1
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Carter, 2008Carter, 2008 0.52[0.02; 12.81]3,04910%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: moderateROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.52[0.02; 12.81]3,0491 -NACarter, 2008 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.52[0.02; 12.81]3,0491 -NACarter, 2008 1 Tags Adjustment   - No  - No 0.52[0.02; 12.81]3,0491 -NACarter, 2008 1 Route of exposure Azoles   - Vaginal  - Vaginal 0.52[0.02; 12.81]3,0491 -NACarter, 2008 1 All studiesAll studies 0.52[0.02; 12.81]3,0491 -NACarter, 2008 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.52[0.02; 12.81]3,0491 -NACarter, 2008 10.510.01.0