Albendazole updated on 01-29-2025

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17534
R73812		 Choi, 2017 Spontaneous abortions 1st trimester prospective cohort unexposed, disease free Adjustment: No Matched 1.27 [0.40;4.30] 4/68   9/192 13 68
ref
S17529
R73759		 Gyapong, 2003 Spontaneous miscarriages early pregnancy retrospective cohort unexposed, sick Adjustment: No Co-administration 1.67 [0.36;7.83] 2/50   7/293 9 50
ref
Total 2 studies 1.41 [0.55;3.60] 22 118
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Choi, 2017Choi, 2017 1.27[0.40; 4.30]136863%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate Gyapong, 2003Gyapong, 2003 1.67[0.36; 7.83]95037%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: criticalROB reporting: moderate Total (2 studies) I2 = 0% 1.41[0.55; 3.60]221180.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.41[0.55; 3.60]221180%NAChoi, 2017 Gyapong, 2003 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.27[0.39; 4.16]1368 -NAChoi, 2017 1 unexposed, sickunexposed, sick 1.67[0.36; 7.79]950 -NAGyapong, 2003 1 Tags Adjustment   - No  - No 1.41[0.55; 3.60]221180%NAChoi, 2017 Gyapong, 2003 2 Co-administrationCo-administration 1.67[0.36; 7.79]950 -NAGyapong, 2003 1 MatchedMatched 1.27[0.39; 4.16]1368 -NAChoi, 2017 1 All studiesAll studies 1.41[0.55; 3.60]221180%NAChoi, 2017 Gyapong, 2003 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.27[0.39; 4.16]1368 -NAChoi, 2017 1 unexposed, sick controlsunexposed, sick controls 1.67[0.36; 7.79]950 -NAGyapong, 2003 10.510.01.0