Albendazole updated on 01-29-2025

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17534
R73813		 Choi, 2017 Major malformations 1st trimester prospective cohort unexposed, disease free Adjustment: Yes Matched 2.20 [0.50;10.10] 3/64   4/183 7 64
ref
Total 1 studies 2.20 [0.49;9.89] 7 64
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Choi, 2017Choi, 2017 2.20[0.50; 10.10]7640%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate0.95.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.20[0.49; 9.89]764 -NAChoi, 2017 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 2.20[0.49; 9.89]764 -NAChoi, 2017 1 Tags Adjustment   - Yes  - Yes 2.20[0.49; 9.89]764 -NAChoi, 2017 1 MatchedMatched 2.20[0.49; 9.89]764 -NAChoi, 2017 1 All studiesAll studies 2.20[0.49; 9.89]764 -NAChoi, 2017 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 2.20[0.49; 9.89]764 -NAChoi, 2017 10.510.01.0