Metronidazole (local route only) updated on 01-29-2025

Microcephaly / Small head circumference for gestational age

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17611
R74360		 Kazy - Metronidazole, 2005 Microcephaly, primary (NOS) during pregnancy (anytime or not specified) case control unexposed (general population or NOS) Adjustment: Yes Route of exposure Azoles: Vaginal 1.30 [0.20;10.50] 2/390   107/37,870 109 390
ref
Total 1 studies 1.30 [0.18;9.42] 109 390
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kazy - Metronidazole, 2005Kazy - Metronidazole, 2005 1.30[0.20; 10.50]1093900%ROB confusion: unclearROB selection: criticalROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.30[0.18; 9.42]109390 -NAKazy - Metronidazole, 2005 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.30[0.18; 9.42]109390 -NAKazy - Metronidazole, 2005 1 Tags Adjustment   - Yes  - Yes 1.30[0.18; 9.42]109390 -NAKazy - Metronidazole, 2005 1 Route of exposure Azoles   - Vaginal  - Vaginal 1.30[0.18; 9.42]109390 -NAKazy - Metronidazole, 2005 1 All studiesAll studies 1.30[0.18; 9.42]109390 -NAKazy - Metronidazole, 2005 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.30[0.18; 9.42]109390 -NAKazy - Metronidazole, 2005 10.510.01.0