Metronidazole (local route only) updated on 01-29-2025

Hypospadias

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17611
R74357		 Kazy - Metronidazole, 2005 Hypospadias 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Route of exposure Azoles: Vaginal 0.70 [0.30;1.50] 10/108   3,028/41,081 3,038 108
ref
Total 1 studies 0.70 [0.31;1.57] 3,038 108
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kazy - Metronidazole, 2005Kazy - Metronidazole, 2005 0.70[0.30; 1.50]3,0381080%ROB confusion: unclearROB selection: criticalROB classification: moderateROB missing: lowROB mesure: unclearROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 0.70[0.31; 1.57]3,038108 -NAKazy - Metronidazole, 2005 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.70[0.31; 1.57]3,038108 -NAKazy - Metronidazole, 2005 1 Tags Adjustment   - Yes  - Yes 0.70[0.31; 1.57]3,038108 -NAKazy - Metronidazole, 2005 1 Route of exposure Azoles   - Vaginal  - Vaginal 0.70[0.31; 1.57]3,038108 -NAKazy - Metronidazole, 2005 1 All studiesAll studies 0.70[0.31; 1.57]3,038108 -NAKazy - Metronidazole, 2005 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.70[0.31; 1.57]3,038108 -NAKazy - Metronidazole, 2005 10.510.01.0