Metronidazole (all routes except local only) updated on 01-29-2025

Very low birth weight (< 1500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17596
R74280		 Piper, 1993 Very low birthweight <1500 g 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 1.15 [0.69;1.92] C 32/1,318   28/1,320 60 1,318
ref
Total 1 studies 1.15 [0.69;1.92] 60 1,318
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Piper, 1993Piper, 1993 1.15[0.69; 1.92]601,3180%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.15[0.69; 1.92]601,318 -NAPiper, 1993 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.15[0.69; 1.92]601,318 -NAPiper, 1993 1 Tags Adjustment   - No  - No 1.15[0.69; 1.92]601,318 -NAPiper, 1993 1 All studiesAll studies 1.15[0.69; 1.92]601,318 -NAPiper, 1993 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.15[0.69; 1.92]601,318 -NAPiper, 1993 10.510.01.0