Metronidazole (all routes except local only) updated on 01-29-2025

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17582
R74193		 Koss, 2012 Low birth weight (< 2,500 g) during pregnancy (anytime or not specified) retrospective cohort unexposed, disease free Adjustment: Yes 0.96 [0.69;1.34] 93/921   169/1,899 262 921
ref
Total 1 studies 0.96 [0.69;1.34] 262 921
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Koss, 2012Koss, 2012 0.96[0.69; 1.34]2629210%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.96[0.69; 1.34]262921 -NAKoss, 2012 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.96[0.69; 1.34]262921 -NAKoss, 2012 1 Tags Adjustment   - Yes  - Yes 0.96[0.69; 1.34]262921 -NAKoss, 2012 1 All studiesAll studies 0.96[0.69; 1.34]262921 -NAKoss, 2012 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.96[0.69; 1.34]262921 -NAKoss, 2012 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Ajiji (Low birth weight (observational studies))Ajiji (Low birth weight (observational studies)) 1.14[0.94; 1.39]35%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT3 Ajiji (Low birth weight (RCT))Ajiji (Low birth weight (RCT)) 1.07[0.72; 1.59]67%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT4 metaPregmetaPreg 0.96[0.69; 1.34]NaN%921----Koss, 2012 10.510.01.0