Metronidazole (all routes except local only) updated on 01-29-2025

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17590
R74237		 Diav-Citrin, 2001 Stillbirths during pregnancy (anytime or not specified) prospective cohort unexposed (general population or NOS) Adjustment: No 0.99 [0.04;24.48] C 0/204   1/608 1 204
ref
S17596
R74279		 Piper, 1993 Still-born infants 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: No 0.50 [0.15;1.67] C 4/1,322   8/1,328 12 1,322
ref
Total 2 studies 0.54 [0.18;1.68] 13 1,526
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Diav-Citrin, 2001Diav-Citrin, 2001 0.99[0.04; 24.48]120412%ROB confusion: criticalROB selection: moderateROB classification: moderateROB missing: criticalROB mesure: criticalROB reporting: moderate Piper, 1993Piper, 1993 0.50[0.15; 1.67]121,32288%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 0.54[0.18; 1.68]131,5260.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.54[0.18; 1.68]131,5260%NADiav-Citrin, 2001 Piper, 1993 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 0.54[0.18; 1.68]131,5260%NADiav-Citrin, 2001 Piper, 1993 2 Tags Adjustment   - No  - No 0.54[0.18; 1.68]131,5260%NADiav-Citrin, 2001 Piper, 1993 2 All studiesAll studies 0.54[0.18; 1.68]131,5260%NADiav-Citrin, 2001 Piper, 1993 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.54[0.18; 1.68]131,5260%NADiav-Citrin, 2001 Piper, 1993 20.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Ajiji (Stillbirths (observational studies))Ajiji (Stillbirths (observational studies)) Out of scale0.42[0.17; 1.03]0%-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT3 Ajiji (Stillbirths (RCT))Ajiji (Stillbirths (RCT)) 1.29[0.51; 3.26]NA-Wwhatever (meta-analysis)Anyduring pregnancy (anytime or not specified)studies TTT1 metaPregmetaPreg 0.54[0.18; 1.68]0%1,526----Diav-Citrin, 2001 Piper, 1993 20.510.01.0