Metronidazole (all routes except local only) - Medication and Pregnancy KB

Metronidazole (all routes except local only) updated on 01-29-2025

Early intrauterine death (< 22 weeks)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S17598 R74293	Muanda b (Controls exposed to penicillins), 2017	Spontaneous abortion (before the 20th week of gestation)	during pregnancy (anytime or not specified)	nested case control	exposed to other treatment, sick excluded	Adjustment: Yes Matched	1.97 [1.45;2.67] excluded (control group)	53/- 8,649/-	8,702	-		ref
S17599 R74294	Muanda b (Controls unexposed, NOS), 2017	Spontaneous abortion (before the 20th week of gestation)	during pregnancy (anytime or not specified)	nested case control	unexposed (general population or NOS)	Adjustment: Yes Matched	1.70 [1.27;2.26]	53/- 8,649/-	8,702	-		ref
S17590 R74235	Diav-Citrin, 2001	Miscarriages	during pregnancy (anytime or not specified)	prospective cohort	unexposed (general population or NOS)	Adjustment: No	1.09 [0.60;1.98] ^C	16/204 44/608	60	204		ref
					Total	2 studies	1.47 [0.98;2.21]		8,762	204
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Controls unexposed, NOS;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 17598

Umbrella review (other published meta-analyses)