Metronidazole (all routes except local only) updated on 01-29-2025

Central Nervous System (CNS) tumors

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17609
R74314		 Thapa, 1998 Central nervous system (CNS) tumors during pregnancy (anytime or not specified) retrospective cohort unexposed (general population or NOS) Adjustment: Yes 1.23 [0.29;5.21] 2/-   28/- 30 -
ref
Total 1 studies 1.23 [0.29;5.21] 30 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Thapa, 1998Thapa, 1998 1.23[0.29; 5.21]30-0%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.23[0.29; 5.21]30- -NAThapa, 1998 1 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.23[0.29; 5.21]30- -NAThapa, 1998 1 Tags Adjustment   - Yes  - Yes 1.23[0.29; 5.21]30- -NAThapa, 1998 1 All studiesAll studies 1.23[0.29; 5.21]30- -NAThapa, 1998 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.23[0.29; 5.21]30- -NAThapa, 1998 10.510.01.0