Metronidazole (all routes except local only) updated on 01-29-2025

Leukemia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17607
R74310		 Pombo-de-Oliveira, 2006 Infant Acute Leukemia during pregnancy (anytime or not specified) case control unexposed (general population or NOS) Adjustment: Yes 1.39 [0.82;2.34] 38/82   164/560 202 82
ref
S17608
R74311		 Ross, 2003 Leukemia (<18 months of age) during pregnancy (anytime or not specified) case control unexposed (general population or NOS) Adjustment: Yes Matched 1.39 [0.33;5.87] 4/8   239/628 243 8
ref
S17606
R74309		 Alexander, 2001 Infant acute leukemia (IAL) (< 18 months of age) 3 months (or more) before pregnancy or during pregnancy excluded case control unexposed (general population or NOS) Adjustment: No Matched 3.59 [0.83;15.41]
excluded (exposition period) 		5/7   131/395 136 7
ref
Total 2 studies 1.39 [0.85;2.27] 445 90
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Pombo-de-Oliveira, 2006Pombo-de-Oliveira, 2006 1.39[0.82; 2.34]2028288%ROB confusion: criticalROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: critical Ross, 2003Ross, 2003 1.39[0.33; 5.87]243812%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: unclearROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.39[0.85; 2.27]445900.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.39[0.85; 2.27]445900%NAPombo-de-Oliveira, 2006 Ross, 2003 2 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.39[0.85; 2.27]445900%NAPombo-de-Oliveira, 2006 Ross, 2003 2 Tags Adjustment   - Yes  - Yes 1.39[0.85; 2.27]445900%NAPombo-de-Oliveira, 2006 Ross, 2003 2 MatchedMatched 1.39[0.33; 5.86]2438 -NARoss, 2003 1 All studiesAll studies 1.39[0.85; 2.27]445900%NAPombo-de-Oliveira, 2006 Ross, 2003 20.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.39[0.85; 2.27]445900%NAPombo-de-Oliveira, 2006 Ross, 2003 20.510.01.0