Metronidazole (all routes except local only) updated on 01-29-2025

Hydrocephaly

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17589
R74224		 Czeizel, 1998 Hydrocephaly 1st trimester case control unexposed (general population or NOS) Adjustment: Yes 3.48 [1.41;8.56] 5/167   273/30,744 278 167
ref
Total 1 studies 3.48 [1.41;8.57] 278 167
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Czeizel, 1998Czeizel, 1998 3.48[1.41; 8.56]2781670%ROB confusion: unclearROB selection: criticalROB classification: moderateROB missing: lowROB mesure: criticalROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 3.48[1.41; 8.57]278167 -NACzeizel, 1998 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.48[1.41; 8.57]278167 -NACzeizel, 1998 1 Tags Adjustment   - Yes  - Yes 3.48[1.41; 8.57]278167 -NACzeizel, 1998 1 All studiesAll studies 3.48[1.41; 8.57]278167 -NACzeizel, 1998 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.48[1.41; 8.57]278167 -NACzeizel, 1998 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Ajiji (Hydrocephaly)Ajiji (Hydrocephaly) 4.06[1.75; 9.42]0%-Wwhatever (meta-analysis)T1+at least 1st trimesterstudies TTT2 metaPregmetaPreg 3.48[1.41; 8.57]NaN%167----Czeizel, 1998 10.510.01.0