Metronidazole (all routes except local only) updated on 01-29-2025

Neural Tube Defects

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17593
R74250		 Medveczky, 2004 Neural-tube defects 1st trimester case control unexposed (general population or NOS) Adjustment: Yes Matched 1.60 [0.70;4.00] 5/90   1,197/39,263 1,202 90
ref
Total 1 studies 1.60 [0.67;3.82] 1,202 90
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Medveczky, 2004Medveczky, 2004 1.60[0.70; 4.00]1,202900%ROB confusion: criticalROB selection: criticalROB classification: moderateROB missing: moderateROB mesure: criticalROB reporting: moderate0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 1.60[0.67; 3.82]1,20290 -NAMedveczky, 2004 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.60[0.67; 3.82]1,20290 -NAMedveczky, 2004 1 Tags Adjustment   - Yes  - Yes 1.60[0.67; 3.82]1,20290 -NAMedveczky, 2004 1 MatchedMatched 1.60[0.67; 3.82]1,20290 -NAMedveczky, 2004 1 All studiesAll studies 1.60[0.67; 3.82]1,20290 -NAMedveczky, 2004 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.60[0.67; 3.82]1,20290 -NAMedveczky, 2004 10.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Ajiji (Neural tube defects)Ajiji (Neural tube defects) 0.66[0.37; 1.18]36%-Wwhatever (meta-analysis)T1+at least 1st trimesterstudies TTT3 metaPregmetaPreg 1.60[0.67; 3.82]NaN%90----Medveczky, 2004 10.510.01.0