Interferon beta (IFN-beta)

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3647
R7582		 Nguyen (control exposed to Glatiramer), 2019 Induced abortion during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.33 [0.48;3.68] C
excluded (control group) 		18/302   5/110 23 302
ref
S3648
R7585		 Nguyen (control unexposed, sick), 2019 Induced abortion during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 1.73 [0.94;3.19] C 18/302   27/763 45 302
ref
S3716
R7996		 Thiel (control unexposed, sick), 2016 Elective abortions early pregnancy prospective cohort unexposed, sick Adjustment: No 0.26 [0.01;6.32] C 0/251   1/194 1 251
ref
S3643
R7874		 Giannini (control exposed to Glatiramer), 2012 Voluntary abortions early pregnancy prospective cohort exposed to other treatment, sick excluded Adjustment: No 2.20 [0.12;41.74] C
excluded (control group) 		5/88   0/17 5 88
ref
S3644
R7875		 Giannini (control unexposed, sick), 2012 Voluntary abortions early pregnancy prospective cohort unexposed, sick Adjustment: No 42.33 [2.32;773.40] C 5/88   0/318 5 88
ref
Total 3 studies 2.57 [0.28;23.52] 51 641
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nguyen (control unexposed, sick), 2019Nguyen, 2019 1 1.73[0.94; 3.19]4530248%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Thiel (control unexposed, sick), 2016Thiel, 2016 2 0.26[0.01; 6.32]125125%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Giannini (control unexposed, sick), 2012Giannini, 2012 3 42.33[2.32; 773.40]58827%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 66% 2.57[0.28; 23.52]516410.2100.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.57[0.28; 23.52]5164166%NANguyen (control unexposed, sick), 2019 Thiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.57[0.28; 23.52]5164166%NANguyen (control unexposed, sick), 2019 Thiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 3 Tags Adjustment   - No  - No 2.57[0.28; 23.52]5164166%NANguyen (control unexposed, sick), 2019 Thiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 3 All studiesAll studies 2.57[0.28; 23.52]5164166%NANguyen (control unexposed, sick), 2019 Thiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 30.1100.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3643, 3647

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.57[0.28; 23.52]5164166%NANguyen (control unexposed, sick), 2019 Thiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.40[0.54; 3.67]283900%NANguyen (control exposed to Glatiramer), 2019 Giannini (control exposed to Glatiramer), 2012 20.510.01.0