Interferon beta (IFN-beta)

Late intrauterine deaths (> 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3716
R7995		 Thiel (control unexposed, sick), 2016 Fetal death early pregnancy prospective cohort unexposed, sick Adjustment: No 0.77 [0.05;12.42] C 1/251   1/194 2 251
ref
S3643
R7561		 Giannini (control exposed to Glatiramer), 2012 Stillbirth early pregnancy prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.57 [0.02;14.67] C
excluded (control group) 		1/88   0/17 1 88
ref
S3644
R7565		 Giannini (control unexposed, sick), 2012 Stillbirth early pregnancy prospective cohort unexposed, sick Adjustment: No 3.64 [0.23;58.85] C 1/88   1/318 2 88
ref
S3723
R8017		 Boskovic (control unexposed, disease free), 2005 Fetal deaths 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 0.90 [0.05;15.49] C
excluded (control group) 		1/22   1/20 2 22
ref
S3724
R8022		 Boskovic (control unexposed, sick), 2005 Fetal deaths 1st trimester prospective cohort unexposed, sick Adjustment: No 3.00 [0.12;78.05] C 1/22   0/21 1 22
ref
Total 3 studies 1.96 [0.36;10.54] 5 361
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Thiel (control unexposed, sick), 2016Thiel, 2016 1 0.77[0.05; 12.42]225137%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Giannini (control unexposed, sick), 2012Giannini, 2012 2 3.64[0.23; 58.85]28837%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Boskovic (control unexposed, sick), 2005Boskovic, 2005 3 3.00[0.12; 78.05]12227%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 1.96[0.36; 10.54]53610.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.96[0.36; 10.54]53610%NAThiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 Boskovic (control unexposed, sick), 2005 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.96[0.36; 10.54]53610%NAThiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 Boskovic (control unexposed, sick), 2005 3 Tags Adjustment   - No  - No 1.96[0.36; 10.54]53610%NAThiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 Boskovic (control unexposed, sick), 2005 3 All studiesAll studies 1.96[0.36; 10.54]53610%NAThiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 Boskovic (control unexposed, sick), 2005 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3723, 3643

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.90[0.05; 15.49]222 -NABoskovic (control unexposed, disease free), 2005 1 unexposed, sick controlsunexposed, sick controls 1.96[0.36; 10.54]53610%NAThiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 Boskovic (control unexposed, sick), 2005 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.57[0.02; 14.67]188 -NAGiannini (control exposed to Glatiramer), 2012 10.510.01.0