Interferon beta (IFN-beta)

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3716
R7989		 Thiel (control unexposed, sick), 2016 Spontaneous abortions early pregnancy prospective cohort unexposed, sick Adjustment: Yes 1.19 [0.56;2.52] 24/251   13/194 37 251
ref
S3643
R7560		 Giannini (control exposed to Glatiramer), 2012 Spontaneous abortion (occurring before 22 completed weeks of gestation) early pregnancy prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.38 [0.16;12.02] C
excluded (control group) 		7/88   1/17 8 88
ref
S3644
R7564		 Giannini (control unexposed, sick), 2012 Spontaneous abortion (occurring before 22 completed weeks of gestation) early pregnancy prospective cohort unexposed, sick Adjustment: No 1.29 [0.53;3.15] C 7/88   20/318 27 88
ref
S3723
R8015		 Boskovic (control unexposed, disease free), 2005 Spontaneous abortions 1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 13.15 [1.48;116.73] C
excluded (control group) 		9/22   1/20 10 22
ref
S3724
R8021		 Boskovic (control unexposed, sick), 2005 Spontaneous abortions 1st trimester prospective cohort unexposed, sick Adjustment: No 2.94 [0.74;11.71] C 9/22   4/21 13 22
ref
Total 3 studies 1.40 [0.82;2.38] 77 361
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Thiel (control unexposed, sick), 2016Thiel, 2016 1 1.19[0.56; 2.52]3725150%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Giannini (control unexposed, sick), 2012Giannini, 2012 2 1.29[0.53; 3.15]278835%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Boskovic (control unexposed, sick), 2005Boskovic, 2005 3 2.94[0.74; 11.71]132215%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 1.40[0.82; 2.38]773610.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.40[0.82; 2.38]773610%NAThiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 Boskovic (control unexposed, sick), 2005 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.40[0.82; 2.38]773610%NAThiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 Boskovic (control unexposed, sick), 2005 3 Tags Adjustment   - No  - No 1.64[0.78; 3.48]401100%NAGiannini (control unexposed, sick), 2012 Boskovic (control unexposed, sick), 2005 2   - Yes  - Yes 1.19[0.56; 2.52]37251 -NAThiel (control unexposed, sick), 2016 1 All studiesAll studies 1.40[0.82; 2.38]773610%NAThiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 Boskovic (control unexposed, sick), 2005 30.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3723, 3643

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) Out of scale13.15[1.48; 116.73]1022 -NABoskovic (control unexposed, disease free), 2005 1 unexposed, sick controlsunexposed, sick controls 1.40[0.82; 2.38]773610%NAThiel (control unexposed, sick), 2016 Giannini (control unexposed, sick), 2012 Boskovic (control unexposed, sick), 2005 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.38[0.16; 12.02]888 -NAGiannini (control exposed to Glatiramer), 2012 10.510.01.0