Interferon beta (IFN-beta)

Jaundice

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3632
R7470		 Fragoso a (control exposed to Glatiramer), 2013 Neonatal jaundice during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.54 [0.24;9.78] C
excluded (control group) 		3/39   2/39 5 39
ref
S3633
R7471		 Fragoso a (control unexposed, sick), 2013 Neonatal jaundice during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 0.91 [0.23;3.61] C 3/39   8/95 11 39
ref
S3636
R7518		 Fragoso b (control exposed to Glatiramer), 2013 Neonatal jaundice at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 5.33 [0.45;63.23] C
excluded (control group) 		2/17   1/41 3 17
ref
S3637
R7535		 Fragoso b (control unexposed, sick), 2013 Neonatal jaundice at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 3.82 [0.59;24.83] C 2/17   3/89 5 17
ref
S3618
R7376		 Finkelsztejn (control exposed to Glatiramer), 2011 Neonatal jaundice early pregnancy retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.47 [0.07;31.84] C
excluded (control group) 		2/69   0/20 2 69
ref
S3619
R7378		 Finkelsztejn (control unexposed, sick), 2011 Neonatal jaundice early pregnancy retrospective cohort unexposed, sick Adjustment: No 1.25 [0.11;14.26] C 2/69   1/43 3 69
ref
Total 3 studies 1.46 [0.53;4.01] 19 125
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fragoso a (control unexposed, sick), 2013Fragoso a, 2013 1 0.91[0.23; 3.61]113953%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Fragoso b (control unexposed, sick), 2013Fragoso b, 2013 2 3.82[0.59; 24.83]51729%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Finkelsztejn (control unexposed, sick), 2011Finkelsztejn, 2011 3 1.25[0.11; 14.26]36917%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 1.46[0.53; 4.01]191250.210.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.46[0.53; 4.01]191250%NAFragoso a (control unexposed, sick), 2013 Fragoso b (control unexposed, sick), 2013 Finkelsztejn (control unexposed, sick), 2011 3 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.46[0.53; 4.01]191250%NAFragoso a (control unexposed, sick), 2013 Fragoso b (control unexposed, sick), 2013 Finkelsztejn (control unexposed, sick), 2011 3 Tags Adjustment   - No  - No 1.46[0.53; 4.01]191250%NAFragoso a (control unexposed, sick), 2013 Fragoso b (control unexposed, sick), 2013 Finkelsztejn (control unexposed, sick), 2011 3 All studiesAll studies 1.46[0.53; 4.01]191250%NAFragoso a (control unexposed, sick), 2013 Fragoso b (control unexposed, sick), 2013 Finkelsztejn (control unexposed, sick), 2011 30.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3618, 3632, 3636

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.46[0.53; 4.01]191250%NAFragoso a (control unexposed, sick), 2013 Fragoso b (control unexposed, sick), 2013 Finkelsztejn (control unexposed, sick), 2011 3 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.19[0.58; 8.32]101250%NAFragoso a (control exposed to Glatiramer), 2013 Fragoso b (control exposed to Glatiramer), 2013 Finkelsztejn (control exposed to Glatiramer), 2011 30.510.01.0