Interferon beta (IFN-beta)

Caesarean

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3716
R7992		 Thiel (control unexposed, sick), 2016 c-Section early pregnancy excluded prospective cohort unexposed, sick Adjustment: Yes 1.21 [0.79;1.87]
excluded (exposition period) 		87/227   60/181 147 227
ref
S3643
R7563		 Giannini (control exposed to Glatiramer), 2012 Caesarean delivery early pregnancy prospective cohort exposed to other treatment, sick excluded Adjustment: No 1.04 [0.35;3.08] C
excluded (control group) 		34/76   7/16 41 76
ref
S3644
R7568		 Giannini (control unexposed, sick), 2012 Caesarean delivery early pregnancy excluded prospective cohort unexposed, sick Adjustment: No 0.84 [0.49;1.44]
excluded (exposition period) 		34/76   130/288 164 76
ref
S3627
R7396		 Lu (control exposed to Glatiramer), 2012 Cesarean section of first live birth during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick excluded Adjustment: No 2.27 [0.08;67.05] C
excluded (control group) 		2/8   0/3 2 8
ref
S3629
R7402		 Lu (control unexposed, sick), 2012 Cesarean section of first live birth during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 0.65 [0.13;3.29] C 2/8   66/194 68 8
ref
Total 1 studies 0.65 [0.13;3.29] 68 8
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lu (control unexposed, sick), 2012Lu, 2012 1 0.65[0.13; 3.29]6880%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.65[0.13; 3.29]688 -NALu (control unexposed, sick), 2012 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.65[0.13; 3.29]688 -NALu (control unexposed, sick), 2012 1 Tags Adjustment   - No  - No 0.65[0.13; 3.29]688 -NALu (control unexposed, sick), 2012 1 All studiesAll studies 0.65[0.13; 3.29]688 -NALu (control unexposed, sick), 2012 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3643, 3627

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.65[0.13; 3.29]688 -NALu (control unexposed, sick), 2012 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.27[0.08; 67.05]28 -NALu (control exposed to Glatiramer), 2012 10.510.01.0