Interferon beta (IFN-beta) - Medication and Pregnancy KB

Interferon beta (IFN-beta)

Neonatal death (< 28 days of life)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S3716 R7997	Thiel (control unexposed, sick), 2016	Early neonatal death (occurring during the first 7 days of life)	early pregnancy	prospective cohort	unexposed, sick	Adjustment: No	2.33 [0.09;57.43] ^C	1/251 0/194	1	251		ref
S3636 R7515	Fragoso b (control exposed to Glatiramer), 2013	Neonatal death (NOS)	at least 1st trimester	retrospective cohort	exposed to other treatment, sick	Adjustment: No	0.80 [0.03;20.62] ^C	0/17 1/41	1	17		ref
					Total	2 studies	1.37 [0.14;13.46]		2	268
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: control unexposed, sick; 2: control exposed to Glatiramer;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded