Interferon beta (IFN-beta)

Preeclampsia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3632
R7436		 Fragoso a (control exposed to Glatiramer), 2013 Preeclampsia during pregnancy (anytime or not specified) retrospective cohort exposed to other treatment, sick excluded Adjustment: No 1.54 [0.24;9.78] C
excluded (control group) 		3/39   2/39 5 39
ref
S3633
R7452		 Fragoso a (control unexposed, sick), 2013 Preeclampsia during pregnancy (anytime or not specified) retrospective cohort unexposed, sick Adjustment: No 2.56 [0.49;13.25] C 3/39   3/95 6 39
ref
S3636
R7510		 Fragoso b (control exposed to Glatiramer), 2013 Pre-eclampsia and eclampsia at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 2.50 [0.15;42.44] C
excluded (control group) 		1/17   1/41 2 17
ref
S3637
R7526		 Fragoso b (control unexposed, sick), 2013 Pre-eclampsia and eclampsia at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 1.33 [0.14;12.67] C 1/17   4/89 5 17
ref
Total 2 studies 2.04 [0.54;7.69] 11 56
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fragoso a (control unexposed, sick), 2013Fragoso a, 2013 1 2.56[0.49; 13.25]63965%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Fragoso b (control unexposed, sick), 2013Fragoso b, 2013 2 1.33[0.14; 12.67]51735%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 2.04[0.54; 7.69]11560.510.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.04[0.54; 7.69]11560%NAFragoso a (control unexposed, sick), 2013 Fragoso b (control unexposed, sick), 2013 2 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 2.04[0.54; 7.69]11560%NAFragoso a (control unexposed, sick), 2013 Fragoso b (control unexposed, sick), 2013 2 Tags Adjustment   - No  - No 2.04[0.54; 7.69]11560%NAFragoso a (control unexposed, sick), 2013 Fragoso b (control unexposed, sick), 2013 2 All studiesAll studies 2.04[0.54; 7.69]11560%NAFragoso a (control unexposed, sick), 2013 Fragoso b (control unexposed, sick), 2013 20.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3632, 3636

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 2.04[0.54; 7.69]11560%NAFragoso a (control unexposed, sick), 2013 Fragoso b (control unexposed, sick), 2013 2 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.78[0.38; 8.37]7560%NAFragoso a (control exposed to Glatiramer), 2013 Fragoso b (control exposed to Glatiramer), 2013 20.510.01.0