Interferon beta (IFN-beta)

Maternal consequences (as a whole)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3636
R7520		 Fragoso b (control exposed to Glatiramer), 2013 Obstetric complications at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.52 [0.13;2.14] C
excluded (control group) 		3/17   12/41 15 17
ref
S3637
R7537		 Fragoso b (control unexposed, sick), 2013 Obstetric complications at least 1st trimester retrospective cohort unexposed, sick Adjustment: No 0.55 [0.15;2.07] C 3/17   25/89 28 17
ref
Total 1 studies 0.55 [0.15;2.07] 28 17
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Fragoso b (control unexposed, sick), 2013Fragoso b, 2013 1 0.55[0.15; 2.07]28170%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.55[0.15; 2.07]2817 -NAFragoso b (control unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 0.55[0.15; 2.07]2817 -NAFragoso b (control unexposed, sick), 2013 1 Tags Adjustment   - No  - No 0.55[0.15; 2.07]2817 -NAFragoso b (control unexposed, sick), 2013 1 All studiesAll studies 0.55[0.15; 2.07]2817 -NAFragoso b (control unexposed, sick), 2013 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3636

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.55[0.15; 2.07]2817 -NAFragoso b (control unexposed, sick), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.52[0.13; 2.14]1517 -NAFragoso b (control exposed to Glatiramer), 2013 10.510.01.0