Zolmitriptan

Major congenital malformations

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3521
R6966		 Spielmann (Control mainly exposed other treatments, sick), 2017 Major birth defects during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 0.95 [0.21;4.34] C
excluded (control group) 		2/75   12/429 14 75
ref
S3522
R6967		 Spielmann (Control unexposed, disease free), 2017 Major birth defects during pregnancy (anytime or not specified) excluded prospective cohort unexposed, disease free Adjustment: No 0.92 [0.22;3.88] C
excluded (exposition period) 		2/75   44/1,526 46 75
ref
S3589
R7253		 Nezvalová-Henriksen (Control unexposed, disease free), 2013 Congenital malformations (major) 1st trimester population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.60 [0.75;3.43]
excluded (control group) 		7/144   5,292/178,565 5,299 144
ref
S3590
R7270		 Nezvalová-Henriksen (Control unexposed, sick), 2013 Congenital malformations (major) 1st trimester population based cohort retrospective unexposed, sick Adjustment: No 1.86 [0.53;6.51] C 7/144   4/150 11 144
ref
Total 1 studies 1.86 [0.53;6.51] 11 144
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nezvalová-Henriksen (Control unexposed, sick), 2013Nezvalová-Henriksen, 2013 1 1.86[0.53; 6.51]111440%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.86[0.53; 6.51]11144 -NANezvalová-Henriksen (Control unexposed, sick), 2013 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.86[0.53; 6.51]11144 -NANezvalová-Henriksen (Control unexposed, sick), 2013 1 Tags Adjustment   - No  - No 1.86[0.53; 6.51]11144 -NANezvalová-Henriksen (Control unexposed, sick), 2013 1 All studiesAll studies 1.86[0.53; 6.51]11144 -NANezvalová-Henriksen (Control unexposed, sick), 2013 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3589, 3521

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.60[0.75; 3.42]5,299144 -NANezvalová-Henriksen (Control unexposed, disease free), 2013 1 unexposed, sick controlsunexposed, sick controls 1.86[0.53; 6.51]11144 -NANezvalová-Henriksen (Control unexposed, sick), 2013 10.510.01.0