Zolmitriptan

All congenital malformations (majors, minors, majors and minors, or unspecified)

id	Study   Auto Spielmann (Control mainly exposed other treatments, sick), 2017Spielmann (Control unexposed, disease free), 2017Nezvalová-Henriksen (Control unexposed, disease free), 2013Nezvalová-Henriksen (Control unexposed, sick), 2013Källén (control exposed to ergots), 2011Källén (control unexposed, disease free), 2011	Lib. in paper	Exposition period  Auto during pregnancy (anytime or not specified)1st trimester2nd trimester3rd trimester2nd and/or 3rd trimesterthroughout pregnancyearly pregnancydays before deliverylate pregnancypreconception-onlypericonceptionalpreconceptional for kinetic reasonat least 1st trimester3 months (or more) before pregnancy or during pregnancy1st and 2nd trimester3 months or more before pregnancy or1st trimester	Study type  All studies Case control excluded Only case control	Control type    Auto unexposed (general population or NOS)unexposed, sickunexposed, disease freeexposed to other treatment, sicknot specifiedwhatever (meta-analysis)	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S3521 R11384	Spielmann (Control mainly exposed other treatments, sick), 2017	Major birth defects	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick excluded	Adjustment: No	0.95 [0.21;4.34] C excluded (control group)	2/75   12/429	14	75		ref
S3522 R11385	Spielmann (Control unexposed, disease free), 2017	Major birth defects	during pregnancy (anytime or not specified) excluded	prospective cohort	unexposed, disease free	Adjustment: No	0.92 [0.22;3.88] C excluded (exposition period)	2/75   44/1,526	46	75		ref
S3589 R7252	Nezvalová-Henriksen (Control unexposed, disease free), 2013	Congenital malformations (any)	1st trimester	population based cohort retrospective	unexposed, disease free excluded	Adjustment: Yes	1.49 [0.80;2.75] excluded (control group)	11/144   9,136/178,565	9,147	144		ref
S3590 R7269	Nezvalová-Henriksen (Control unexposed, sick), 2013	Congenital malformations (any)	1st trimester	population based cohort retrospective	unexposed, sick	Adjustment: No	1.47 [0.57;3.76] C	11/144   8/150	19	144		ref
S3504 R6836	Källén (control exposed to ergots), 2011	Any congenital malformations	1st trimester	population based cohort propective	exposed to other treatment, sick excluded	Adjustment: No	0.83 [0.40;1.70] C excluded (control group)	12/362   21/527	33	362		ref
S3497 R6822	Källén (control unexposed, disease free), 2011	Any congenital malformations	1st trimester	population based cohort propective	unexposed, disease free	Adjustment: No	0.76 [0.43;1.35]	12/362   56,759/1,229,901	56,771	362		ref
					Total	2 studies	0.95 [0.52;1.74]		56,790	506
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

Sensitivity analysis

Publication bias and p-hacking diagnosis

Sub-groups analysis using all included studies

excluded 3504, 3589, 3521