Naratriptan

Elective/induced termination of pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3553
R7062		 Yusuf (Control exposed to Sumatriptan), 2018 Elective abortions 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No 0.95 [0.44;2.05] C 7/190   136/3,496 143 190
ref
S3489
R6729		 Ephross (Naratriptan versus Sumatriptan), 2014 Induced abortions during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick Adjustment: No 0.68 [0.09;5.23] C 1/57   16/626 17 57
ref
Total 2 studies 0.91 [0.44;1.87] 160 247
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yusuf (Control exposed to Sumatriptan), 2018Yusuf, 2018 1 0.95[0.44; 2.05]14319087%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Ephross (Naratriptan versus Sumatriptan), 2014Ephross, 2014 2 0.68[0.09; 5.23]175713%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 0.91[0.44; 1.87]1602470.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control exposed to Sumatriptan; 2: Naratriptan versus Sumatriptan;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.91[0.44; 1.87]1602470%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 2 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.91[0.44; 1.87]1602470%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 2 Tags Adjustment   - No  - No 0.91[0.44; 1.87]1602470%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 2 All studiesAll studies 0.91[0.44; 1.87]1602470%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 20.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.91[0.44; 1.87]1602470%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 20.510.01.0