Naratriptan

Early intrauterine death (< 22 weeks)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3553
R7063		 Yusuf (Control exposed to Sumatriptan), 2018 Spontaneous abortion (NOS) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No 0.96 [0.65;1.41] C 33/190   629/3,496 662 190
ref
S3489
R6726		 Ephross (Naratriptan versus Sumatriptan), 2014 Spontaneous loss (<20 weeks of gestation) 1st trimester prospective cohort exposed to other treatment, sick Adjustment: No 1.55 [0.58;4.14] C 5/52   34/528 39 52
ref
Total 2 studies 1.02 [0.71;1.46] 701 242
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Yusuf (Control exposed to Sumatriptan), 2018Yusuf, 2018 1 0.96[0.65; 1.41]66219087%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Ephross (Naratriptan versus Sumatriptan), 2014Ephross, 2014 2 1.55[0.58; 4.14]395213%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (2 studies) I2 = 0% 1.02[0.71; 1.46]7012420.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control exposed to Sumatriptan; 2: Naratriptan versus Sumatriptan;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.02[0.71; 1.46]7012420%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 2 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 1.02[0.71; 1.46]7012420%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 2 Tags Adjustment   - No  - No 1.02[0.71; 1.46]7012420%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 2 All studiesAll studies 1.02[0.71; 1.46]7012420%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.02[0.71; 1.46]7012420%NAYusuf (Control exposed to Sumatriptan), 2018 Ephross (Naratriptan versus Sumatriptan), 2014 20.510.01.0