Sumatriptan

Low birth weight (< 2500g)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3581
R7147		 Nezvalová-Henriksen (Control unexposed, disease free), 2013 Birth weight < 2,500 g during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 1.25 [0.87;1.82]
excluded (control group) 		31/575   7,168/178,565 7,199 575
ref
S3582
R7165		 Nezvalová-Henriksen (Control unexposed, sick), 2013 Birth weight < 2,500 g during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: No 0.71 [0.42;1.21] C 31/575   27/364 58 575
ref
S3542
R7019		 Kallen, 2001 Low birth weight (< 2500 g, singletons) early pregnancy population based cohort retrospective unexposed (general population or NOS) Adjustment: No 1.18 [0.70;1.97] 25/658   -/- 16 658
ref
S3531
R6976		 Olesen (Control unexposed, disease free), 2000 LBW (< 2500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, disease free excluded Adjustment: Yes 2.30 [0.30;17.60]
excluded (control group) 		1/34   291/15,995 292 34
ref
S3530
R6974		 Olesen (Control unexposed, sick), 2000 LBW (< 2500 g) during pregnancy (anytime or not specified) population based cohort retrospective unexposed, sick Adjustment: Yes 0.90 [0.10;11.80] 1/34   5/89 6 34
ref
Total 3 studies 0.92 [0.64;1.33] 80 1,267
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nezvalová-Henriksen (Control unexposed, sick), 2013Nezvalová-Henriksen, 2013 1 0.71[0.42; 1.21]5857547%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Kallen, 2001Kallen, 2001 1.18[0.70; 1.97]1665850%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Olesen (Control unexposed, sick), 2000Olesen, 2000 2 0.90[0.10; 11.80]6342%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA Total (3 studies) I2 = 0% 0.92[0.64; 1.33]801,2670.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: Control unexposed, sick; 2: Control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.92[0.64; 1.33]801,2670%NANezvalová-Henriksen (Control unexposed, sick), 2013 Kallen, 2001 Olesen (Control unexposed, sick), 2000 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.18[0.70; 1.98]16658 -NAKallen, 2001 1 unexposed, sickunexposed, sick 0.72[0.43; 1.21]646090%NANezvalová-Henriksen (Control unexposed, sick), 2013 Olesen (Control unexposed, sick), 2000 2 Tags Adjustment   - No  - No 0.92[0.56; 1.51]741,23344%NANezvalová-Henriksen (Control unexposed, sick), 2013 Kallen, 2001 2   - Yes  - Yes 0.90[0.08; 9.78]634 -NAOlesen (Control unexposed, sick), 2000 1 All studiesAll studies 0.92[0.64; 1.33]801,2670%NANezvalová-Henriksen (Control unexposed, sick), 2013 Kallen, 2001 Olesen (Control unexposed, sick), 2000 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3531, 3581

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.24[0.92; 1.67]7,5071,2670%NANezvalová-Henriksen (Control unexposed, disease free), 2013 Kallen, 2001 Olesen (Control unexposed, disease free), 2000 3 unexposed, sick controlsunexposed, sick controls 0.72[0.43; 1.21]646090%NANezvalová-Henriksen (Control unexposed, sick), 2013 Olesen (Control unexposed, sick), 2000 20.510.01.0