Sumatriptan - Medication and Pregnancy KB

Sumatriptan

Late intrauterine deaths (> 22 weeks)

R analysis

id	Study	Lib. in paper	Exposition period	Study type All studies Case control excluded Only case control	Control type	Tags	OR 95%CI	x1/n1 x0/n0	no cases	no exposed	ROB	Ref.
S3552 R7056	Yusuf (Control exposed to Naratriptan), 2018	Stillbirth (NOS)	1st trimester	retrospective cohort (claims database)	exposed to other treatment, sick	Adjustment: No	1.58 [0.09;26.56] ^C	14/3,496 0/190	14	3,496		ref
S3488 R6724	Ephross (Control exposed to Naratriptan), 2014	Fetal death (≥20 weeks of gestation)	during pregnancy (anytime or not specified)	prospective cohort	exposed to other treatment, sick	Adjustment: No	1.00 [0.05;18.35] ^C	5/626 0/57	5	626		ref
S3532 R6981	O'Quinn, 1999	Stillbirth (NOS)	1st trimester	prospective cohort	unexposed, sick	Adjustment: No	0.40 [0.02;9.95] ^C	0/76 1/92	1	76		ref
					Total	3 studies	0.91 [0.16;5.06]		20	4,198
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; ^C: calculated odds ratio from numbers of events and effectives

Forest plot

1: Control exposed to Naratriptan; 2: Control exposed to Naratriptan;

Sensitivity analysis

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded