Thiouracil, propylthiouracil, benzylthiouracil

Maternal liver disorder / failure during pregnancy

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3377
R6584		 Lo (control exposed to MMI), 2015 Maternal hepatotoxicity during pregnancy (anytime or not specified) retrospective cohort (claims database) exposed to other treatment, sick Adjustment: No 0.42 [0.02;10.52] C 1/556   0/79 1 556
ref
S3387
R6578		 Korelitz (control exposed to MMI), 2013 Livers disorders in pregnancy (in mothers) 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 2.35 [0.10;57.78] C
excluded (control group) 		1/1,533   0/1,201 1 1,533
ref
S8718
R29466		 Korelitz (control exposed to MMI), 2013 Livers disorders in pregnancy (in mothers) 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 2.35 [0.10;57.78] C
excluded (control group) 		1/1,533   0/1,201 1 1,533
ref
S3388
R6579		 Korelitz (control unexposed, disease free), 2013 Livers disorders in pregnancy (in mothers) 3rd trimester retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 0.81 [0.11;5.79] C
excluded (control group) 		1/1,533   642/801,375 643 1,533
ref
S3389
R6580		 Korelitz (control unexposed, sick), 2013 Livers disorders in pregnancy (in mothers) 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 0.35 [0.04;2.80] C
excluded (exposition period) 		1/1,533   9/4,902 10 1,533
ref
Total 1 studies 0.42 [0.02;10.52] 1 556
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Lo (control exposed to MMI), 2015Lo, 2015 1 0.42[0.02; 10.52]15560%ROB confusion: criticalROB selection: lowROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control exposed to MMI;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.42[0.02; 10.52]1556 -NALo (control exposed to MMI), 2015 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.42[0.02; 10.52]1556 -NALo (control exposed to MMI), 2015 1 Tags Adjustment   - No  - No 0.42[0.02; 10.52]1556 -NALo (control exposed to MMI), 2015 1 All studiesAll studies 0.42[0.02; 10.52]1556 -NALo (control exposed to MMI), 2015 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3387, 8718, 3388

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 0.81[0.11; 5.79]6431,533 -NAKorelitz (control unexposed, disease free), 2013 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls Out of scale0.42[0.02; 10.52]1556 -NALo (control exposed to MMI), 2015 10.510.01.0