Carbimazole, Thiamazole (Methimazole)

Urinary malformations

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3447
R6445
Andersen (control exposed to PTU), 2019 Urinary system (Q60-64) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.97 [0.38;2.47] C
excluded (control group)
12/1,574   7/889 19 1,574
ref
S3446
R6430
Andersen (control unexposed, disease free), 2019 Urinary system (Q60-64) early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 2.15 [1.22;3.80] C 12/1,574   4,125/1,159,181 4,137 1,574
ref
S3364
R6135
Seo (control exposed to PTU), 2018 Urinary system (Q60–Q64) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.89 [0.38;2.06] C
excluded (control group)
6/1,120   60/9,930 66 1,120
ref
S3365
R6147
Seo (control unexposed, NOS), 2018 Urinary system (Q60–Q64) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.09 [0.49;2.43] 6/1,120   13,494/2,872,109 13,500 1,120
ref
S3337
R5709
Andersen 2017 (control exposed to PTU), 2017 Urinary system early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 0.45 [0.05;4.32] C
excluded (control group)
1/162   3/218 4 162
ref
S3335
R5674
Andersen 2017 (control unexposed, disease free), 2017 Urinary system early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 1.48 [0.21;10.60] C
excluded (control group)
1/162   2,846/682,343 2,847 162
ref
S3336
R5688
Andersen 2017 (control unexposed, sick), 2017 Urinary system early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 1.37 [0.17;11.21] C 1/162   7/1,551 8 162
ref
S3386
R6304
Korelitz (control exposed to PTU), 2013 Congenital anomalies of urinary system 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.56 [0.03;9.92] C
excluded (control group)
0/108   7/915 7 108
ref
S3384
R6288
Korelitz (control unexposed, disease free), 2013 Congenital anomalies of urinary system 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 1.06 [0.07;17.02] C
excluded (control group)
0/108   2,780/634,858 2,780 108
ref
S3385
R6296
Korelitz (control unexposed, sick), 2013 Congenital anomalies of urinary system 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 0.91 [0.05;15.23] C
excluded (exposition period)
0/108   16/3,236 16 108
ref
Total 3 studies 1.69 [1.08;2.67] 17,645 2,856
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen (control unexposed, disease free), 2019Andersen, 2019 1 2.15[1.22; 3.80]4,1371,57463%ROB confusion: seriousROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Seo (control unexposed, NOS), 2018Seo, 2018 2 1.09[0.49; 2.43]13,5001,12032%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 3 1.37[0.17; 11.21]81625%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.69[1.08; 2.67]17,6452,8560.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, NOS; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.69[1.08; 2.67]17,6452,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.63[0.84; 3.13]17,6372,69446%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 2 unexposed, sickunexposed, sick 1.37[0.17; 11.21]8162 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 2.09[1.20; 3.61]4,1451,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2   - Yes  - Yes 1.09[0.49; 2.43]13,5001,120 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.69[1.08; 2.67]17,6452,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3386, 3384, 3337, 3335, 3364, 3447

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.70[1.08; 2.67]20,4842,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 3 unexposed, sick controlsunexposed, sick controls 1.37[0.17; 11.21]8162 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.88[0.48; 1.60]892,8560%NAAndersen (control exposed to PTU), 2019 Seo (control exposed to PTU), 2018 Andersen 2017 (control exposed to PTU), 2017 30.510.01.0