Carbimazole, Thiamazole (Methimazole)

Abdominal wall defects

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3447
R6447
Andersen (control exposed to PTU), 2019 Muscoloskeletal system, others (Q79) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 8.51 [0.49;149.15] C
excluded (control group)
7/1,574   0/889 7 1,574
ref
S3446
R6432
Andersen (control unexposed, disease free), 2019 Muscoloskeletal system, others (Q79) early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 5.59 [2.65;11.79] C 7/1,574   925/1,159,181 932 1,574
ref
S3337
R6641
Andersen 2017 (control exposed to PTU), 2017 Muscoloskeletal system, others (Q79) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.35 [0.03;68.24] C
excluded (control group)
0/162   0/218 0 162
ref
S3335
R6642
Andersen 2017 (control unexposed, disease free), 2017 Muscoloskeletal system, others (Q79) early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 3.94 [0.25;63.38] C
excluded (control group)
0/162   535/682,343 535 162
ref
S3336
R6643
Andersen 2017 (control unexposed, sick), 2017 Muscoloskeletal system, others (Q79) early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 3.20 [0.13;78.83] C 0/162   1/1,551 1 162
ref
Total 2 studies 5.44 [2.63;11.23] 933 1,736
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen (control unexposed, disease free), 2019Andersen, 2019 1 5.59[2.65; 11.79]9321,57495%ROB confusion: seriousROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 2 3.20[0.13; 78.83]11625%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 5.44[2.63; 11.23]9331,7360.920.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 5.44[2.63; 11.23]9331,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 5.59[2.65; 11.79]9321,574 -NAAndersen (control unexposed, disease free), 2019 1 unexposed, sickunexposed, sick 3.20[0.13; 78.83]1162 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 5.44[2.63; 11.23]9331,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2 All studiesAll studies 5.44[2.63; 11.23]9331,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 20.520.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3337, 3335, 3447

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 5.46[2.66; 11.22]1,4671,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, disease free), 2017 2 unexposed, sick controlsunexposed, sick controls 3.20[0.13; 78.83]1162 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 4.48[0.44; 45.34]71,7360%NAAndersen (control exposed to PTU), 2019 Andersen 2017 (control exposed to PTU), 2017 20.510.01.0