Carbimazole, Thiamazole (Methimazole)

Respiratory system anomalies

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3447
R6442
Andersen (control exposed to PTU), 2019 Respiratory system early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.08 [0.54;2.19] C
excluded (control group)
23/1,574   12/889 35 1,574
ref
S3446
R6427
Andersen (control unexposed, disease free), 2019 Respiratory system early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 1.77 [1.17;2.67] C 23/1,574   9,636/1,159,181 9,659 1,574
ref
S3364
R6131
Seo (control exposed to PTU), 2018 Respiratory system (Q30–Q34) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.11 [0.33;3.69] C
excluded (control group)
3/1,120   24/9,930 27 1,120
ref
S3365
R6143
Seo (control unexposed, NOS), 2018 Respiratory system (Q30–Q34) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.20 [0.39;3.73] 3/1,120   6,317/2,872,109 6,320 1,120
ref
S3337
R5706
Andersen 2017 (control exposed to PTU), 2017 Respiratory system early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 4.07 [0.16;100.45] C
excluded (control group)
1/162   0/218 1 162
ref
S3335
R5671
Andersen 2017 (control unexposed, disease free), 2017 Respiratory system early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 0.53 [0.07;3.77] C
excluded (control group)
1/162   7,927/682,343 7,928 162
ref
S3336
R5685
Andersen 2017 (control unexposed, sick), 2017 Respiratory system early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 0.53 [0.07;3.99] C 1/162   18/1,551 19 162
ref
S3386
R6302
Korelitz (control exposed to PTU), 2013 Congenital anomalies of respiratory system 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 0.77 [0.04;14.01] C
excluded (control group)
0/108   5/915 5 108
ref
S3384
R6286
Korelitz (control unexposed, disease free), 2013 Congenital anomalies of respiratory system 3 months (or more) before pregnancy or during pregnancy retrospective cohort (claims database) unexposed, disease free excluded Adjustment: No 1.72 [0.11;27.65] C
excluded (control group)
0/108   1,714/634,858 1,714 108
ref
S3385
R6294
Korelitz (control unexposed, sick), 2013 Congenital anomalies of respiratory system 3 months (or more) before pregnancy or during pregnancy excluded retrospective cohort (claims database) unexposed, sick Adjustment: No 1.77 [0.10;30.80] C
excluded (exposition period)
0/108   8/3,236 8 108
ref
Total 3 studies 1.62 [1.11;2.37] 15,998 2,856
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen (control unexposed, disease free), 2019Andersen, 2019 1 1.77[1.17; 2.67]9,6591,57485%ROB confusion: seriousROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Seo (control unexposed, NOS), 2018Seo, 2018 2 1.20[0.39; 3.73]6,3201,12011%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 3 0.53[0.07; 3.99]191624%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.62[1.11; 2.37]15,9982,8560.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, NOS; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.62[1.11; 2.37]15,9982,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.69[1.15; 2.49]15,9792,6940%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 2 unexposed, sickunexposed, sick 0.53[0.07; 3.99]19162 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 1.47[0.63; 3.44]9,6781,73624%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2   - Yes  - Yes 1.20[0.39; 3.71]6,3201,120 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.62[1.11; 2.37]15,9982,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 30.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3386, 3384, 3337, 3335, 3364, 3447

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.62[1.11; 2.37]23,9072,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 3 unexposed, sick controlsunexposed, sick controls 0.53[0.07; 3.99]19162 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.14[0.63; 2.07]632,8560%NAAndersen (control exposed to PTU), 2019 Seo (control exposed to PTU), 2018 Andersen 2017 (control exposed to PTU), 2017 30.510.01.0