Carbimazole, Thiamazole (Methimazole)

Congenital heart defects

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3447
R6441
Andersen (control exposed to PTU), 2019 Circulatory system (Q20-28) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.39 [0.77;2.50] C
excluded (control group)
39/1,574   16/889 55 1,574
ref
S3446
R6426
Andersen (control unexposed, disease free), 2019 Circulatory system (Q20-28) early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 1.91 [1.39;2.63] C 39/1,574   15,195/1,159,181 15,234 1,574
ref
S3364
R6130
Seo (control exposed to PTU), 2018 Circulatory system (Q20–Q28) 1st trimester retrospective cohort (claims database) exposed to other treatment, sick excluded Adjustment: No 1.60 [1.14;2.25] C
excluded (control group)
41/1,120   230/9,930 271 1,120
ref
S3365
R6142
Seo (control unexposed, NOS), 2018 Circulatory system (Q20–Q28) 1st trimester retrospective cohort (claims database) unexposed (general population or NOS) Adjustment: Yes 1.60 [1.17;2.19] 41/1,120   62,086/2,872,109 62,127 1,120
ref
S3337
R5705
Andersen 2017 (control exposed to PTU), 2017 Circulatory systems early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 2.76 [0.68;11.19] C
excluded (control group)
6/162   3/218 9 162
ref
S3335
R5670
Andersen 2017 (control unexposed, disease free), 2017 Circulatory systems early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 1.98 [0.88;4.48] C
excluded (control group)
6/162   12,981/682,343 12,987 162
ref
S3336
R5684
Andersen 2017 (control unexposed, sick), 2017 Circulatory systems early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 1.53 [0.64;3.68] C 6/162   38/1,551 44 162
ref
Total 3 studies 1.73 [1.40;2.15] 77,405 2,856
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen (control unexposed, disease free), 2019Andersen, 2019 1 1.91[1.39; 2.63]15,2341,57446%ROB confusion: seriousROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Seo (control unexposed, NOS), 2018Seo, 2018 2 1.60[1.17; 2.19]62,1271,12048%ROB confusion: criticalROB selection: moderateROB classification: lowROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 3 1.53[0.64; 3.68]441626%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (3 studies) I2 = 0% 1.73[1.40; 2.15]77,4052,8560.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, NOS; 3: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.73[1.40; 2.15]77,4052,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 3 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.75[1.40; 2.18]77,3612,6940%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 2 unexposed, sickunexposed, sick 1.53[0.64; 3.68]44162 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 1.86[1.38; 2.51]15,2781,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2   - Yes  - Yes 1.60[1.17; 2.19]62,1271,120 -NASeo (control unexposed, NOS), 2018 1 All studiesAll studies 1.73[1.40; 2.15]77,4052,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, sick), 2017 30.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3337, 3335, 3364, 3447

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.76[1.42; 2.19]90,3482,8560%NAAndersen (control unexposed, disease free), 2019 Seo (control unexposed, NOS), 2018 Andersen 2017 (control unexposed, disease free), 2017 3 unexposed, sick controlsunexposed, sick controls 1.53[0.64; 3.68]44162 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.58[1.19; 2.11]3352,8560%NAAndersen (control exposed to PTU), 2019 Seo (control exposed to PTU), 2018 Andersen 2017 (control exposed to PTU), 2017 30.510.01.0