Carbimazole, Thiamazole (Methimazole)

Neonatal hyperthyrotropinemia

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3563
R7099		 Gianetti (control exposed to PTU), 2015 Transient hyperthyropinemia (elevated serum TSH) at least 1st trimester retrospective cohort exposed to other treatment, sick excluded Adjustment: No 0.62 [0.10;3.82] C
excluded (control group) 		3/124   2/52 5 124
ref
S3562
R7088		 Gianetti (control unexposed, sick), 2015 Transient hyperthyropinemia (elevated serum TSH) at least 1st trimester excluded retrospective cohort unexposed, sick Adjustment: No 11.76 [0.60;229.71] C
excluded (exposition period) 		3/124   0/203 3 124
ref
S3468
R6635		 Momotani (control exposed to PTU), 1997 Fetal TSH levels above the normal range throughout pregnancy prospective cohort exposed to other treatment, sick Adjustment: No 0.63 [0.19;2.07] C 6/43   7/34 13 43
ref
Total 1 studies 0.63 [0.19;2.07] 13 43
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Momotani (control exposed to PTU), 1997Momotani, 1997 1 0.63[0.19; 2.07]13430%ROB confusion: criticalROB selection: unclearROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate0.22.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control exposed to PTU;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0.63[0.19; 2.07]1343 -NAMomotani (control exposed to PTU), 1997 1 case control studiescase control studies 0 Type of controls exposed to other treatment, sickexposed to other treatment, sick 0.63[0.19; 2.07]1343 -NAMomotani (control exposed to PTU), 1997 1 Tags Adjustment   - No  - No 0.63[0.19; 2.07]1343 -NAMomotani (control exposed to PTU), 1997 1 All studiesAll studies 0.63[0.19; 2.07]1343 -NAMomotani (control exposed to PTU), 1997 10.210.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3563

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls exposed to other treatment, sick controlsexposed to other treatment, sick controls 0.63[0.19; 2.07]1343 -NAMomotani (control exposed to PTU), 1997 10.510.01.0