Carbimazole, Thiamazole (Methimazole)

Syndromes and chromosomal abnormalities

R analysis
id Study   Lib. in paper Exposition period    Study type  Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3447
R6449
Andersen (control exposed to PTU), 2019 Other malformations (Q85-99) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 1.27 [0.39;4.14] C
excluded (control group)
9/1,574   4/889 13 1,574
ref
S3446
R6434
Andersen (control unexposed, disease free), 2019 Other malformations (Q85-99) early pregnancy population based cohort retrospective unexposed, disease free Adjustment: No 1.20 [0.62;2.31] C 9/1,574   5,532/1,159,181 5,541 1,574
ref
S3337
R5712
Andersen 2017 (control exposed to PTU), 2017 Other malformations (Q85-99) early pregnancy population based cohort retrospective exposed to other treatment, sick excluded Adjustment: No 4.07 [0.16;100.45] C
excluded (control group)
1/162   0/218 1 162
ref
S3335
R5677
Andersen 2017 (control unexposed, disease free), 2017 Other malformations (Q85-99) early pregnancy population based cohort retrospective unexposed, disease free excluded Adjustment: No 1.73 [0.24;12.35] C
excluded (control group)
1/162   2,443/682,343 2,444 162
ref
S3336
R5691
Andersen 2017 (control unexposed, sick), 2017 Other malformations (Q85-99) early pregnancy population based cohort retrospective unexposed, sick Adjustment: No 0.87 [0.11;6.78] C 1/162   11/1,551 12 162
ref
Total 2 studies 1.16 [0.62;2.17] 5,553 1,736
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Andersen (control unexposed, disease free), 2019Andersen, 2019 1 1.20[0.62; 2.31]5,5411,57491%ROB confusion: seriousROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Andersen 2017 (control unexposed, sick), 2017Andersen 2017, 2017 2 0.87[0.11; 6.78]121629%ROB confusion: criticalROB selection: moderateROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 0% 1.16[0.62; 2.17]5,5531,7360.25.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, disease free; 2: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.16[0.62; 2.17]5,5531,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2 case control studiescase control studies 0 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 1.20[0.62; 2.31]5,5411,574 -NAAndersen (control unexposed, disease free), 2019 1 unexposed, sickunexposed, sick 0.87[0.11; 6.78]12162 -NAAndersen 2017 (control unexposed, sick), 2017 1 Tags Adjustment   - No  - No 1.16[0.62; 2.17]5,5531,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 2 All studiesAll studies 1.16[0.62; 2.17]5,5531,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, sick), 2017 20.25.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3337, 3335, 3447

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 1.24[0.67; 2.32]7,9851,7360%NAAndersen (control unexposed, disease free), 2019 Andersen 2017 (control unexposed, disease free), 2017 2 unexposed, sick controlsunexposed, sick controls 0.87[0.11; 6.78]12162 -NAAndersen 2017 (control unexposed, sick), 2017 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 1.46[0.48; 4.43]141,7360%NAAndersen (control exposed to PTU), 2019 Andersen 2017 (control exposed to PTU), 2017 20.510.01.0