Diuretics (versus unexposed) updated on 03-11-2025

Early intrauterine deaths (< 22 weeks) / Spontaneous abortions

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S17121
R71662		 Van der Zande - Diuretics, 2024 Reported miscarriage (NOS) 1st trimester prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 2.77 [1.67;4.59] C 18/191   194/5,357 212 191
ref
S14259
R56062		 Leather - Bendrofluazide, 1968 Abortion during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Co-administration Indications Antihypertensive: Only chronic hypertension indication 0.13 [0.01;2.68] C 0/23   3/24 3 23
ref
Total 2 studies 0.88 [0.05;15.98] 215 214
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Van der Zande - Diuretics, 2024Van der Zande - Diuretics, 2024 2.77[1.67; 4.59]21219162%ROB confusion: criticalROB selection: lowROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate Leather - Bendrofluazide, 1968Leather - Bendrofluazide, 1968 0.13[0.01; 2.68]32338%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 74% 0.88[0.05; 15.98]2152140.010.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.77[1.67; 4.59]212191 -NAVan der Zande - Diuretics, 2024 1 case control studiescase control studies 0 RCTRCT 0.13[0.01; 2.68]323 -NALeather - Bendrofluazide, 1968 1 Type of controls unexposed, sickunexposed, sick 0.88[0.05; 15.98]21521474%NAVan der Zande - Diuretics, 2024 Leather - Bendrofluazide, 1968 2 Tags Adjustment   - No  - No 2.77[1.67; 4.59]212191 -NAVan der Zande - Diuretics, 2024 1   - Randomisation  - Randomisation 0.13[0.01; 2.68]323 -NALeather - Bendrofluazide, 1968 1 Co-administrationCo-administration 0.13[0.01; 2.68]323 -NALeather - Bendrofluazide, 1968 1 Indications Antihypertensive   - Only cardiac indications other than ...  - Only cardiac indications other than hypertension (long QT syndrome, structural heart disease, ...) 2.77[1.67; 4.59]212191 -NAVan der Zande - Diuretics, 2024 1   - Only chronic hypertension indication  - Only chronic hypertension indication 0.13[0.01; 2.68]323 -NALeather - Bendrofluazide, 1968 1 All studiesAll studies 0.88[0.05; 15.98]21521474%NAVan der Zande - Diuretics, 2024 Leather - Bendrofluazide, 1968 20.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.88[0.05; 15.98]21521474%NAVan der Zande - Diuretics, 2024 Leather - Bendrofluazide, 1968 20.510.01.0