Diuretics (versus unexposed) updated on 03-11-2025

Neuroblastoma

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S14143
R55473		 Schwartzbaum - Diuretics, 1992 Neuroblastoma 3 months (or more) before pregnancy or during pregnancy excluded case control unexposed (general population or NOS) Adjustment: Yes Indications Antihypertensive: All hypertensions, any indications or not specified 2.50 [0.90;6.70]
excluded (exposition period) 		7/-   94/- 101 -
ref
S14184
R55600		 Kramer - Diuretics, 1987 Neuroblastoma - Median diagnosis 1 year old during pregnancy (anytime or not specified) case control unexposed (general population or NOS) Adjustment: No Indications Antihypertensive: All hypertensions, any indications or not specified Matched 3.00 [1.34;6.73] -/-   95/- - -
ref
Total 1 studies 3.00 [1.34;6.72] 0 0
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Kramer - Diuretics, 1987Kramer - Diuretics, 1987 3.00[1.34; 6.73]--0%ROB confusion: seriousROB selection: criticalROB classification: criticalROB missing: lowROB mesure: moderateROB reporting: moderate0.910.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 0 case control studiescase control studies 3.00[1.34; 6.72]-- -NAKramer - Diuretics, 1987 1 Type of controls unexposed (disease free or unspecified)unexposed (disease free or unspecified) 3.00[1.34; 6.72]-- -NAKramer - Diuretics, 1987 1 Tags Adjustment   - No  - No 3.00[1.34; 6.72]-- -NAKramer - Diuretics, 1987 1 Indications Antihypertensive   - All hypertensions, any indications ...  - All hypertensions, any indications or not specified 3.00[1.34; 6.72]-- -NAKramer - Diuretics, 1987 1 MatchedMatched 3.00[1.34; 6.72]-- -NAKramer - Diuretics, 1987 1 All studiesAll studies 3.00[1.34; 6.72]-- -NAKramer - Diuretics, 1987 10.510.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed controls (disease free or unspecified)unexposed controls (disease free or unspecified) 3.00[1.34; 6.72]86- -NAKramer - Diuretics, 1987 10.510.01.0