Diuretics (versus unexposed) updated on 03-11-2025

Perinatal death

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S13514
R52205		 Mabie - Hydrochlorothiazide, 1986 Perinatal death (stillbirth and neonatal deaths) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No Indications Antihypertensive: Only chronic hypertension indication 2.82 [0.11;74.36] C 0/10   1/82 1 10
ref
S14259
R56063		 Leather - Bendrofluazide, 1968 Perinatal death during pregnancy (anytime or not specified) randomized controlled trial unexposed, sick Adjustment: Randomisation Co-administration Indications Antihypertensive: Only chronic hypertension indication 0.19 [0.01;4.21] C 0/23   2/24 2 23
ref
Total 2 studies 0.70 [0.05;9.72] 3 33
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Mabie - Hydrochlorothiazide, 1986Mabie - Hydrochlorothiazide, 1986 2.82[0.11; 74.36]11048%ROB confusion: criticalROB selection: moderateROB classification: unclearROB missing: unclearROB mesure: moderateROB reporting: moderate Leather - Bendrofluazide, 1968Leather - Bendrofluazide, 1968 0.19[0.01; 4.21]22352%ROB confusion: lowROB selection: unclearROB classification: moderateROB missing: lowROB mesure: moderateROB reporting: moderate Total (2 studies) I2 = 27% 0.70[0.05; 9.72]3330.010.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 2.82[0.11; 74.36]110 -NAMabie - Hydrochlorothiazide, 1986 1 case control studiescase control studies 0 RCTRCT 0.19[0.01; 4.21]223 -NALeather - Bendrofluazide, 1968 1 Type of controls unexposed, sickunexposed, sick 0.70[0.05; 9.72]33327%NAMabie - Hydrochlorothiazide, 1986 Leather - Bendrofluazide, 1968 2 Tags Adjustment   - No  - No 2.82[0.11; 74.36]110 -NAMabie - Hydrochlorothiazide, 1986 1   - Randomisation  - Randomisation 0.19[0.01; 4.21]223 -NALeather - Bendrofluazide, 1968 1 Co-administrationCo-administration 0.19[0.01; 4.21]223 -NALeather - Bendrofluazide, 1968 1 Indications Antihypertensive   - Only chronic hypertension indication  - Only chronic hypertension indication 0.70[0.05; 9.72]33327%NAMabie - Hydrochlorothiazide, 1986 Leather - Bendrofluazide, 1968 2 All studiesAll studies 0.70[0.05; 9.72]33327%NAMabie - Hydrochlorothiazide, 1986 Leather - Bendrofluazide, 1968 20.010.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 0.70[0.05; 9.72]33327%NAMabie - Hydrochlorothiazide, 1986 Leather - Bendrofluazide, 1968 20.510.01.0

Umbrella review (other published meta-analyses)

Published MAControlPeriodTE95% CIn exposedkI2 Churchill (Perinatal death)Churchill (Perinatal death) 0.72[0.40; 1.27]0%-U,Sunexposed, sickAnyduring pregnancy (anytime or not specified)studies TTT5 metaPregmetaPreg 0.70[0.05; 9.72]27%33----Mabie - Hydrochlorothiazide, 1986 Leather - Bendrofluazide, 1968 20.510.01.0