Natalizumab

Intrauterine deaths (as a whole or unspecified)

R analysis
id Study   Lib. in paper Exposition period    Study type 
 Control type 
 
Tags OR 95%CI x1/n1 x0/n0 no cases no exposed ROB Ref.
S3656
R7596		 Nguyen (control exposed to IFN), 2019 Spontaneous abortion/Miscarriage (NOS) during pregnancy (anytime or not specified) prospective cohort exposed to other treatment, sick excluded Adjustment: No 2.04 [0.84;4.96] C
excluded (control group) 		8/78   16/302 24 78
ref
S3657
R7599		 Nguyen (control unexposed, sick), 2019 Spontaneous abortion/Miscarriage (NOS) during pregnancy (anytime or not specified) prospective cohort unexposed, sick Adjustment: No 1.63 [0.74;3.58] C 8/78   50/763 58 78
ref
S3770
R8056		 Ebrahimi (control unexposed, disease free), 2015 Spontaneous abortions 3 months or more before pregnancy or1st trimester prospective cohort unexposed, disease free excluded Adjustment: No 4.93 [1.59;15.25] C
excluded (control group) 		17/98   4/98 21 98
ref
S3769
R8049		 Ebrahimi (control unexposed, sick), 2015 Spontaneous abortions 3 months or more before pregnancy or1st trimester excluded prospective cohort unexposed, sick Adjustment: No 0.79 [0.38;1.62] C
excluded (exposition period) 		17/98   20/95 37 98
ref
Total 1 studies 1.63 [0.74;3.58] 58 78
x1: number of endpoints among exposed, n1: number of exposed; x0: number of endpoints among non exposed, n0: number of non exposed; C: calculated odds ratio from numbers of events and effectives

Forest plot

StudyTE95% CIn casesn exposedweightROBABCDEF Nguyen (control unexposed, sick), 2019Nguyen, 2019 1 1.63[0.74; 3.58]58780%ROB confusion: NAROB selection: NAROB classification: NAROB missing: NAROB mesure: NAROB reporting: NA0.55.01.0ROB: A: confusion, B: selection, C: classification, D: missing, E: measurement, F: reportinglow,moderate,serious,critical,unclear,

1: control unexposed, sick;

Sensitivity analysis

SubsetTE95% CIn casesn exposedkI2 Type of studies cohort studiescohort studies 1.63[0.74; 3.58]5878 -NANguyen (control unexposed, sick), 2019 1 case control studiescase control studies 0 Type of controls unexposed, sickunexposed, sick 1.63[0.74; 3.58]5878 -NANguyen (control unexposed, sick), 2019 1 Tags Adjustment   - No  - No 1.63[0.74; 3.58]5878 -NANguyen (control unexposed, sick), 2019 1 All studiesAll studies 1.63[0.74; 3.58]5878 -NANguyen (control unexposed, sick), 2019 10.55.01.0

Publication bias and p-hacking diagnosis

funnel plot

Funnel plot not drawn. Less than 3 points.

Asymetry test p-value = NaN (by Egger's regression)

not enought points

p values plot

Funnel plot not drawn. Less than 3 points.

Sub-groups analysis using all included studies

excluded 3770, 3656

Sub-groupsTE95% CIn casesn exposedkI2ROB type of controls unexposed, sick controlsunexposed, sick controls 1.63[0.74; 3.58]5878 -NANguyen (control unexposed, sick), 2019 1 exposed to other treatment, sick controlsexposed to other treatment, sick controls 2.04[0.84; 4.96]2478 -NANguyen (control exposed to IFN), 2019 10.510.01.0